Friday, January 13, 2012

Mayo Clinic Islet Cell Transplants to Improve Diabetes after Partial Pancreas Removal

ROCHESTER, Minn.  Sometimes doctors have to surgically remove a portion, or a person's entire pancreas. Infections and inflammation can shut down the pancreas. The natural result when the pancreas fails is diabetes &mdash often called pancreatogenic diabetes. The Mayo Clinic has been experimenting with pancreatic islets in select patients undergoing partial pancreas removal. Its most recent report on the progress of the procedure has found that the procedure shows promise for reducing the effects of diabetes related to pancreatogenic diabetes.

As you know, the pancreas is a gland organ that secretes hormones to regulate blood sugar levels and produces enzymes that break down digestible foods. Pancreatitis causes painful inflammation in the abdomen that occurs when digestive enzymes attack the pancreas, affecting digestion and the hormones that help control blood sugar levels. Severe inflammation of the pancreas can cause separation of the pancreatic duct between the right and left portions of the gland, a condition known as disconnected pancreatic duct syndrome.

"After attempts to control pain and improve malabsorption problems have been exhausted, total or near-total removal of the pancreas is recommended for patients with severe cases of pancreatitis in which pancreas tissue dies," says Santhi Swaroop Vege, M.D., a gastroenterologist at Mayo Clinic. "Such surgery, however, often results in a type of diabetes known as pancreatogenic diabetes."

Pancreatic islet autotransplantation (a transplant using a person's own tissue) is one treatment option to prevent pancreatogenic diabetes caused by pancreatic surgery. The procedure involves isolation and purification of insulin-producing cells (islets) after the pancreas, or a portion of the pancreas, is surgically removed in patients for whom pancreatic cancer is not a concern. The purified islets are then infused in the patient's portal vein, a large vein that carries blood from the digestive tract to the liver. The islets gradually implant in the liver and begin producing insulin.

Approximately 30 medical centers in North America have islet isolation laboratories. At these centers, pancreatic islet autotransplantation is a recommended procedure for patients undergoing total or near-total pancreatectomy. But according to Dr. Vege, half of patients undergoing distal or extended distal pancreatectomy (removal of 50 percent to 70 percent of the pancreas) will also develop pancreatogenic diabetes.

The Mayo Clinic islet autotransplantation team studied whether pancreatic islet autotransplantation is a feasible treatment option for patients undergoing distal or extended distal pancreatectomy after severe pancreatitis and disconnected pancreatic duct syndrome. The team attempted pancreatic islet autotransplantation on seven patients who were undergoing removal of 50 percent to 70 percent of their pancreas. In four patients, the removed portion of the pancreas contained insufficient insulin-producing islets. The remaining three patients received the procedure. Of those, two did not develop pancreatogenic diabetes and one developed a less-complicated case of pancreatogenic diabetes.

"Our initial experience with pancreatic islet autotransplantation in this patient population shows that the procedure is a feasible treatment option," says Dr. Kudva. "Long-term follow-up, expansion to additional patients and research studies will help us better understand the full utility of this procedure."
Sponsored Ads
Buy Instagram Followers
5000+ Instagram Followers & Likes. Fast Delivery!
Business Class Flights to Europe

Why does this matter to people with diabetes?

If a diabetic person's pancreas is partially or completely failing, islet cell transplantation may be able to help restore some insulin production. As physicians learn how to have higher success rates with islet transplantation, it may be able to help millions of people. However, if insulin resistance is contributing to a person's diabetes, islet transplantation does not directly address the problem. A person confronting diabetic insulin resistance should work with exercise, diet and medication to help their muscles and fat tissue re-energize its ability to use insulin properly.


  1. This comment has been removed by a blog administrator.

  2. People don't take it serious at all. They even don't know how much insulin is necessary for them in a day. Well this blog might help them.midwifery personal statement ucas

  3. Hillary Whyte is my name; i suffered Diabetes for several years. My sugar level was as high as anything you can think about. i looked for how to get rid of this diabetes for a long period of time, but could not found any solution. Though i have always believed on herbal medicine, but was never chanced to look for any because of my political carrier. But not too long i saw some good news on the internet on how a herbal doctor cured so many persons of various diseases, and viruses. So i also decided to contact the doctor those people talked about he is by the name Doctor Uwadia Amenifo. I emailed him, and i explained my problem to him, he said he has the cure for diabetes and i decided to give him a try because there is no harm in trying. So i started the process, and he prepared some herbs, and sent it to me here in my country, so i began to use it, and behold it worked for me like a magic. I am happy to say today i am diabetes free, and my sugar level is back to normalcy. Please if you also have same, and or similar problem please rush to contact Doctor Uwadia Amenifo before it becomes too late for you. His email is and his phone number is +2349052015874. Just email, or call him.

  4. I'm here to testify about the great work Dr sunshine did for me. I have been suffering from Diabetes for the past 3 years and had constant pain, especially in my lungs. During the first year,I had faith in God that i would be healed someday.This illness started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Ogidigan on how he cured her Diabetes and she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about Diabetes, he told me not to worry that i was going to be cured, Well i never believed it, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over my body system as Dr Ogidi assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally cured behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr Ogidigan via email: Thanks