tag:blogger.com,1999:blog-4608855889289635032024-03-26T23:37:41.024-07:00Wireless LibrariesWireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-460885588928963503.post-15084572826657779342012-01-13T17:29:00.000-08:002014-08-21T14:25:11.736-07:00Grain Fiber and Magnesium Intake Associated With Lower Risk for Diabetes<br />
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Higher dietary intake of fiber from grains, cereals, and
magnesium, may each be associated with a lower risk of type 2 diabetes,
according to a report and analysis in the May 14 issue of Archives of Internal
Medicine, one of the JAMA/Archives journals.<o:p></o:p></div>
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Projections indicate that the number of people diagnosed
with diabetes worldwide may increase from 171 million in 2000 to 370 million by
2030, according to background information in the article. The associated
illness, death, and health care costs emphasize the need for effective
prevention, the authors write. Fiber may help reduce the risk of diabetes by
increasing the amount of nutrients absorbed by the body and reducing blood
sugar spikes after eating, among other mechanisms. Current American Diabetes
Association guidelines include goals for total fiber intake, but research
suggests that some types of fiber may be more beneficial than others. Findings
regarding magnesium and diabetes risk remain unclear.<o:p></o:p></div>
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Dr. Matthias B. Schulze, and colleagues at the German
Institute of Human Nutrition, conducted a study of 9,702 men and 15,365 women
age 35 to 65 years. Participants completed a food questionnaire when they
enrolled in the study between 1994 and 1998, then were followed up through
2005—an average of seven years—to see if they developed diabetes. In addition,
the researchers performed a meta-analysis of previously published work related
to intake of fiber or magnesium and risk of diabetes.<o:p></o:p></div>
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During the follow-up period, 844 individuals in the study
developed type 2 diabetes. Those who consumed more fiber through cereal, bread,
and other grain products (cereal fiber), were less likely to develop diabetes
than those who ate less fiber. When the participants were split into five
groups based on cereal fiber intake, those who ate the most (an average of 29
grams per day) had a 27 percent lower risk of developing diabetes than those in
the group that ate the least (an average of 15.1 grams per day). Eating more
fiber overall or from fruits and vegetables was not associated with diabetes
risk, nor was magnesium intake.</div>
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In the meta-analysis, the researchers identified nine
studies of fiber and eight studies of magnesium intake. Based on the results of
all the studies, in which participants were classified into either four or five
groups according to their intake of fiber or magnesium, those who consumed the
most cereal fiber had a 33% percent lower risk of developing diabetes than those
who took in the least, while those who consumed the most magnesium had a
23percent lower risk than those who consumed the least. There was no
association between fruit or vegetable fiber and diabetes risk.<o:p></o:p></div>
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"The evidence from our study and previous studies,
summarized by means of meta-analysis, strongly supports that higher cereal
fiber and magnesium intake may decrease diabetes risk," the authors
conclude. "Whole-grain foods are therefore important in diabetes
prevention."</blockquote>
Read More:<br />
<a href="http://wirelesslibraries.blogspot.com/2012/01/chromium-study-does-not-prove-benefit.html">Chromium Study Does Not Prove Benefit to Diabetes</a> - A study out of the Netherlands<br />
<a href="http://wirelesslibraries.blogspot.com/2012/01/lessons-learned-from-popular-diabetes.html">Lessons Learned from Popular Diabetes Strategy</a> - Weight Loss Surgery<br />
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Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com6tag:blogger.com,1999:blog-460885588928963503.post-40653987771508137622012-01-13T17:28:00.000-08:002014-05-29T14:30:09.034-07:00Mayo Clinic Islet Cell Transplants to Improve Diabetes after Partial Pancreas Removal<br />
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ROCHESTER, Minn. Sometimes doctors have to
surgically remove a portion, or a person's entire pancreas. Infections and
inflammation can shut down the pancreas. The natural result when the pancreas
fails is diabetes &mdash often called pancreatogenic diabetes. The Mayo
Clinic has been experimenting with pancreatic islets in select patients
undergoing partial pancreas removal. Its most recent report on the progress of
the procedure has found that the procedure shows promise for reducing the
effects of diabetes related to pancreatogenic diabetes.<o:p></o:p></div>
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As you know, the pancreas is a gland organ that secretes
hormones to regulate blood sugar levels and produces enzymes that break down
digestible foods. Pancreatitis causes painful inflammation in the abdomen that
occurs when digestive enzymes attack the pancreas, affecting digestion and the
hormones that help control blood sugar levels. Severe inflammation of the
pancreas can cause separation of the pancreatic duct between the right and left
portions of the gland, a condition known as disconnected pancreatic duct
syndrome.<o:p></o:p></div>
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"After attempts to control pain and improve
malabsorption problems have been exhausted, total or near-total removal of the
pancreas is recommended for patients with severe cases of pancreatitis in which
pancreas tissue dies," says Santhi Swaroop Vege, M.D., a
gastroenterologist at Mayo Clinic. "Such surgery, however, often results
in a type of diabetes known as pancreatogenic diabetes."</blockquote>
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Pancreatic islet autotransplantation (a transplant using a
person's own tissue) is one treatment option to prevent pancreatogenic diabetes
caused by pancreatic surgery. The procedure involves isolation and purification
of insulin-producing cells (islets) after the pancreas, or a portion of the
pancreas, is surgically removed in patients for whom pancreatic cancer is not a
concern. The purified islets are then infused in the patient's portal vein, a
large vein that carries blood from the digestive tract to the liver. The islets
gradually implant in the liver and begin producing insulin.<o:p></o:p></div>
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Approximately 30 medical centers in North America have islet
isolation laboratories. At these centers, pancreatic islet autotransplantation
is a recommended procedure for patients undergoing total or near-total
pancreatectomy. But according to Dr. Vege, half of patients undergoing distal
or extended distal pancreatectomy (removal of 50 percent to 70 percent of the
pancreas) will also develop pancreatogenic diabetes.<o:p></o:p></div>
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The Mayo Clinic islet autotransplantation team studied
whether pancreatic islet autotransplantation is a feasible treatment option for
patients undergoing distal or extended distal pancreatectomy after severe
pancreatitis and disconnected pancreatic duct syndrome. The team attempted
pancreatic islet autotransplantation on seven patients who were undergoing
removal of 50 percent to 70 percent of their pancreas. In four patients, the
removed portion of the pancreas contained insufficient insulin-producing
islets. The remaining three patients received the procedure. Of those, two did
not develop pancreatogenic diabetes and one developed a less-complicated case
of pancreatogenic diabetes.<o:p></o:p></div>
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"Our initial experience with pancreatic islet
autotransplantation in this patient population shows that the procedure is a
feasible treatment option," says Dr. Kudva. "Long-term follow-up,
expansion to additional patients and research studies will help us better
understand the full utility of this procedure."</blockquote>
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<b>Why does this matter to people with diabetes?</b><o:p></o:p></div>
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If a diabetic person's pancreas is partially or completely
failing, islet cell transplantation may be able to help restore some insulin
production. As physicians learn how to have higher success rates with islet
transplantation, it may be able to help millions of people. However, if insulin
resistance is contributing to a person's diabetes, islet transplantation does
not directly address the problem. A person confronting diabetic insulin
resistance should work with exercise, diet and medication to help their muscles
and fat tissue re-energize its ability to use insulin properly.<o:p></o:p></div>
Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com12tag:blogger.com,1999:blog-460885588928963503.post-59048968397784097702012-01-13T17:27:00.001-08:002012-01-13T17:27:18.773-08:00Chromium Study Does Not Prove Benefit to Diabetes<br />
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A study out of the Netherlands, and published in the journal
Diabetes Care, found that chromium yeast was not beneficial to people with type
2 diabetes. The study lasted six months and enrolled about 60 patients.
Chromium yeast is also known as Baker's yeast.<o:p></o:p></div>
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Chromium has been the subject of a number of studies in
conjunction with diabetes. Most of the studies have found that chromium has
little or no effect on improving blood sugar measures. However, there was one
recent study that showed some benefit from chromium picolinate. Still, one
study is not as compelling as all of the studies that proceeded it with
disappointing results. We would like to see continuously good science before we
can get incredibly excited about chromium. Please check with your doctor. Her
or his opinion should weigh more heavily on your decision than our short update
here.<o:p></o:p></div>
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<i><span style="color: #666666;">Sources: Diabetes Care, ClinicalTrials.gov</span></i><o:p></o:p></div>Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com5tag:blogger.com,1999:blog-460885588928963503.post-26177662285483026162012-01-13T17:26:00.001-08:002012-01-13T17:26:46.232-08:00Japanese Diabetes Drug May Take Four Years to Make it to USA<br />
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A drug company can decide which countries it wants to
introduce its drugs into first. Here in the United States, we assume drug
companies will introduce them here first. Usually American drug companies
introduce drugs in the United States. But drug companies in Europe often apply
for approval there. The same holds true with Japan, Israel, and other counties
where there are quite a few drug-producing companies.<o:p></o:p></div>
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Glufast, or mitiglinide calcium hydrate, is a diabetes
medication from Japan, that has been in use there since 2004. It improves the
body's own ability to produce insulin, and has the tendency to lower post-meal
glucose levels in its users. However, it is not on the market in the United
States. It is not even yet being considered by the FDA for approval. The
company that owns the rights to market Glufast in North America, Elixir
Pharmaceuticals, Inc., plans to submit a new drug application with the FDA in
2008. This is the way it goes in the global health care system.<o:p></o:p></div>Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com5tag:blogger.com,1999:blog-460885588928963503.post-64858612396807571692012-01-13T17:18:00.001-08:002012-01-13T17:18:16.094-08:00Conflicting Interpretations of Data for Diabetes Medication Rosiglitazone<br />
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Because of the uproar in the diabetes community fueled by a
New England Journal of Medicine (NEJM) last week, the publication decided to
release some preliminary findings in an article about an additional study on
rosiglitazone (brand name Avandia). But even these preliminary findings are
open to a lot of interpretation, and audiences are drawing different
conclusions . One of todays' headlines read Diabetes drugmaker cites
"reassuring" study, while another national media outlet captioned
with Newest Avandia Study Not Reassuring. Even in the New England Journal of
Medicine there were three different editorial pieces, all putting forth
different interpretations of this data. Keep in mind that this is only
preliminary.<o:p></o:p></div>
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We are amazed at what science has accomplished, and its
ability to prolong life and heal. We are beneficiaries of that marvel. However,
it is still appropriate to recognize that science has its limitations. For the
last few weeks we've been confronting one of them. It is challenging enough to
measure one issue, like a drug's ability to lower blood sugar levels. (Avandia
does it very well.) It is even harder to measure the next generation of
questions such as heart attacks. Taking such measures requires years of outcome
data from very large numbers of patients.<o:p></o:p></div>
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My Diabetes Information wants science to measure these
issues. We are not going to make excuses for adverse events. However, we do
want to state that each and every one of us that uses any type of medication
needs to realize that science has not been able to uncover or measure many of
the risks that exist when we take advantage of the focused benefit that comes
in a pill.<o:p></o:p></div>Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com3tag:blogger.com,1999:blog-460885588928963503.post-61622563697032218972012-01-13T17:17:00.001-08:002012-01-13T17:19:54.171-08:00Lessons Learned from Popular Diabetes Strategy - Weight Loss Surgery<br />
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CHICAGO — There are millions of people battling diabetes
that are not able to control their weight using diet and exercise alone. Their
genetics and other factors have programmed them to be obese. If they are
insulin dependant, insulin may actually make them more prone to be overweight.
Medicare has recently begun covering bariatric (weight loss) surgery although
significant death rates have previously been reported in Medicare patients
undergoing the procedure. However, the risks of death and other complications
after bariatric surgery appear similar between patients younger and older than
age 60, and also between Medicare recipients and non-recipients, according to a
study in the June issue of Archives of Surgery, one of the JAMA/Archives
journals.<o:p></o:p></div>
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"Obesity has become the leading cause of preventable
death in the United States," according to background information in the
article. "Rates of obesity have continued to climb in the last decade
across all age groups. Surgery for morbid obesity is currently the most
effective treatment." The success of bariatric surgery has expanded the
treatment of morbid (severe) obesity and its conditions for patient populations
that had not previously been served. Peter T. Hallowell, M.D., and colleagues
of University Hospitals Case Medical Center and Case Western Reserve University
School of Medicine, Cleveland, reviewed the cases of 892 patients who had
gastric bypass surgery from 1998 to 2006. The patients were divided into four
groups:<o:p></o:p></div>
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<div class="MsoListParagraphCxSpFirst" style="mso-list: l1 level1 lfo1; text-indent: -.25in;">
<span style="font-family: Symbol;">·<span style="font: normal normal normal 7pt/normal 'Times New Roman';">
</span></span>Group one, 46 patients age 60 to 66 years was
compared with group two, 846 patients age 18 to 59 years.<o:p></o:p></div>
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<span style="font-family: Symbol;">·<span style="font: normal normal normal 7pt/normal 'Times New Roman';">
</span></span>Group three, 31 Medicare recipients (age 31 to
66), was compared with group four, 861 non-Medicare recipients (age 18 to 64).<o:p></o:p></div>
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The age, sex and body mass index of each patient were
documented as well as time spent in the operating room, length of stay, other
illnesses and complications — including death. When the research team analyzed
the data, they found:<o:p></o:p></div>
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<span style="font-family: Symbol;">·<span style="font: normal normal normal 7pt/normal 'Times New Roman';">
</span></span>When comparing older (group one) and younger
(group two) patients, the male-female ratios and the BMIs were similar between
both groups.<o:p></o:p><br />
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<span style="font-family: Symbol;">·<span style="font: normal normal normal 7pt/normal 'Times New Roman';">
</span></span>The average length of the hospital stay was a
half-day longer for group one than for group two.<o:p></o:p></div>
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<span style="font-family: Symbol;">·<span style="font: normal normal normal 7pt/normal 'Times New Roman';">
</span></span>The older group spent an average of 17 minutes
less in the operating room than the younger group.<o:p></o:p></div>
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<span style="font-family: Symbol;">·<span style="font: normal normal normal 7pt/normal 'Times New Roman';">
</span></span>There was no statistically significant
difference found between the two groups for any postoperative complication or
death.<o:p></o:p><br />
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"No mortality was seen in the older group (group one)
at 30 days, 90 days or one year. Three deaths occurred within 30 days in the
younger group (group two) with one additional death within one year," the
authors note.<o:p></o:p></div>
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When comparing Medicare and non-Medicare patients, group
three (Medicare patients) had a greater average BMI of 56 and spent an average
of 14 minutes longer in the operating room. Medicare patients also spent an
average of a day-and-a-half longer in the hospital. There was no significant
difference between the two groups for any complication or death after surgery.
No Medicare patients died at 30 days, 90 days or one year. Three non-Medicare
patients died within 30 days and one additional patient died within one year.<o:p></o:p></div>
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"Bariatric surgery can be performed in carefully
selected Medicare recipients and patients 60 years or older with acceptable
morbidity and mortality," the authors conclude. "We believe that
these results reflect careful patient selection, intensive preoperative
education and expert operative and perioperative management. Our results
indicate that bariatric surgery should not be denied solely based on age or
Medicare status."<o:p></o:p></div>
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If you are considering weight loss surgery, you should
consult with your physician that helps you manage your diabetes. Your doctor
will have a pretty good idea how beneficial weight loss surgery could be for
you, and he or she will be able to weight the risks against the potential
rewards.<o:p></o:p></div>
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<i><span style="color: #666666;">Source: American Medical Association, Archives of Surgery.
2007;142:506-512.</span></i></div>Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com2tag:blogger.com,1999:blog-460885588928963503.post-66452355635551019772012-01-13T17:16:00.003-08:002012-01-13T17:16:40.408-08:00Being Literate About Your Health Could Save Your Life<br />
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Just the fact that you are reading this means that you are
looking for medical information. We often refer to health literacy as simply
the ability to speak intelligently with your doctor about your condition. We
hope My Diabetes Information is helping you maintain your literacy.<o:p></o:p></div>
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A study reported today from Northwestern University suggests
that people who are health literate tend to live longer with health conditions
than those who do not understand their illness. It seems logical that a person
who understands his or her condition could strategize better. It is also likely
that he or she would recognize symptoms of potentially dangerous situations and
address them.<o:p></o:p></div>
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So, keep reading and learning, and keep listening to your
body. It is likely to pay off by improving your physical health, as well as
making you feel better.<o:p></o:p></div>Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com2tag:blogger.com,1999:blog-460885588928963503.post-91506939123083038432012-01-13T17:16:00.001-08:002012-01-13T17:16:11.947-08:00Bone Protein Osteocalcin Also Important to Blood Sugar<br />
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When we pass on scientific experiments from animal studies
we are careful because they do not often turn out the same in humans. However,
a recent study from Columbia University Medical Center conducted with mice
revealed how important the bone compound osteocalcin is to the endocrine
system.<o:p></o:p></div>
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Osteocalcin signals the pancreas to create more insulin. It
also signals fat cells to release the valuable compound adiponectin.<o:p></o:p></div>
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The Columbia University scientists point out, "People
with type 2 diabetes have been shown to have low osteocalcin levels, suggesting
that altering the activity of this molecule could be an effective
therapy."<o:p></o:p></div>
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As the research goes forward, it may reveal how we can
improve skeletal health, and maintain a healthy endocrine system.<o:p></o:p></div>Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com2tag:blogger.com,1999:blog-460885588928963503.post-85319513308101199942012-01-13T17:15:00.001-08:002012-01-13T17:15:42.578-08:00Genes May Determine Response to Metformin for Diabetes<br />
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Your genes may be signaling how well you respond to
metformin. If you have the right genetic
makeup, metformin may lower your A1C score to a healthy level. A change or variation in gene that tells the
body how to create a small structure with cells call an organic cation
transporter 1 (OCT1) contributes to metformin's effectiveness. (A simplified explanation of an organic
cation transporter is a chemical that helps certain atoms to enter a cell.)<o:p></o:p></div>
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In a recent clinical trial, people who had genetic variations
that reduced the function of OCT1 also had less success at lowering blood
glucose with metformin. This study does not suggest that patients considering
metformin take a genetic test. Perhaps that will occur someday. For now, if
metformin is not helping you control your blood sugar, the best strategy may be
to combine another medication with it, or switch to a different mediction
altogether. Your doctor will be your best resource for making this
decision. <o:p></o:p></div>
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The Wall Street Journal published an article about genes and
medications back in August, that is more general than diabetes. It highlights
an individual very sensitive to the blood thinner warafin. It reinforces the
fact that there is always a risk with medications, and people can have strange
unforseen reactions. Medicine is amazing in most cases, but it is good to
realize that problems can occur.<o:p></o:p></div>Wireless Librarieshttp://www.blogger.com/profile/00018232616664358224noreply@blogger.com1